Roger Butterworth, PhD
Disclosures: Nothing to disclose
Date of birth:

              BIOGRAPHICAL SKETCH – ROGER F. BUTTERWORTH

CURRENT POSITIONS  Professor of Medicine, University of Montreal and Scientific Director, Neuroscience Research Unit, St-Luc Hospital, Montreal

 

QUALIFICATIONS

B.Sc. (Honours), Biochemistry and Physics, University of London 1966

Ph.D., Biochemistry, University of London 1969

D.Sc., Neurological Sciences, University of London 1996

 

RESEARCH AND TEACHING APPOINTMENTS

1970-72              Postdoctoral Research Fellow, Department of Chemistry, University of Montreal

1972-74              Research Associate, Laboratory of Neurobiology, Clinical Research Institute of Montreal (University of Montreal)

1975-79              Research Fellow, Assistant Director, Department of Neurobiology, Clinical Research Institute of Montreal (University of Montreal)

1976-82              Assistant Professor, Department of Medicine, University of Montreal

1979-83              Director, Laboratory of Neurochemistry, Clinical Research Institute of Montreal (University of Montreal)

1982-84              Visiting Professor, Department of Health Sciences, Concordia University

1983-89              Associate Professor, Department of Medicine, University of Montreal

1983-89                Senior Research Fellow, FRSQ

1983-1992              Director, Laboratory of Neurochemistry, André-Viallet Clinical Research Centre, Hôpital Saint-Luc (University of Montreal)

1985-2014              Member, Research Center in Neurological Sciences, University of Montreal

1986-2014              Member, University of Montreal Research Group in Hepatology

1986                            Visiting Scientist, INSERM U-29, Hôpital Port-Royal, Paris, France

1989-present              Full Professor, Department of Medicine, University of Montreal

1990-present              Adjunct Professor, Department of Experimental Medicine, McGill University

1991-1995              Associated scientist and member, Research Ethics Board, Douglas Hospital Research Centre, McGill University

1992                            Visiting Professor, Clinical Pharmacology Institute, University of Lund Hospital, Lund, Sweden.

1992-2014              Scientific Director, Neuroscience Research Unit, Hôpital Saint-Luc (CHUM, University of Montreal)

1996                            Visiting Professor, Dept. of Pathology, University of Sydney, Sydney, Australia.

1999-2007              Adjunct Professor, Dept. of Biochemistry, University of Queensland, Brisbane, Australia

1999-2005              Associate Researcher, Sacré-Coeur Hospital Research Centre, University of Montreal

2000                            Visiting Professor, Instituto Investigaciones Citologicas de la Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain

 

MEDALS, HONOURS

Awarded 'Order of Senegal' medal for contribution to the advancement of Neuroscience in Africa, Dakar, Senegal, 1998

Awarded Gold Medal of Canadian Liver Foundation, Banff, Alberta, 2003

President, International Society for Neurochemistry (ISN), 2006-2007

President, International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) 2009-2011

“Andy Blei Lecture”, ISHEN, 2014

 

COMMITTEES

Member, Ad Hoc Review Committee, Developmental Neuroscience Program, National Science

Foundation, Washington, D.C., 1986

Member, NIH site visit team to University of Michigan, PET Center, August 1991

Member, Executive Board, André-Viallet Clinical Research Center, 1991-1997

Member, NIH evaluation team, Dept. of Pediatrics, University of Baltimore, Baltimore, USA, November

1993

Member, Scholarship Awards Committee, Medical Research Council of Canada, 1993-1996

Member, NIH Site Visit Team, Dept. of Pediatrics, University of Baltimore, MD, USA, March 1997

Member, Molecular and Cellular Neurosciences Study Section, NIH, Bethesda, October 1998

Member, Consultative Committee on Research Priorities in the CHUM, March 1999

Member, Committee for renovation of André-Viallet Clinical Research Centre, CHUM, March 1999

Members and consultant, NIH/Fogarty Foundation meeting on research and support priorities in Africa, Washington DC, April 2002

Member, NIH consultant team to Dept. of Pediatrics, University of Baltimore, USA, June 2002

Member, NIH Molecular and cellular Neuroscience Study Sections, Washington DC, June 2003

 

EDITORIAL EXPERIENCE

1984-1990               Member, Editorial board, “Metabolic Brain Disease

1987                            Editor, special issue of “Neurochemical Pathology”, publication of ASN Symposium entitled "Neurochemical Consequences of Hepatic Disease"

1988                            Guest Editor, “Neuromethods”, Volume 15, “Carbohydrates and Energy Metabolism”

1988-present              Member, Editorial Board, “Behavioral and Brain Functions

1989                            Editor, “Hepatic Encephalopathy:  Pathophysiology and Treatment”, Humana Press, U.S.A.

1989-2010              Member, Editorial Board, “Hepatology

1990                            Editor, “(Mal) Nutrition and the Infant Brain”, Alan Liss, U.S.A.

1990-1994               Associate Editor, “Metabolic Brain Disease

1992                              Guest Editor, “Neuromethods”, Volumes 22 and 23, "Animal Models of Neurological Disease"

1993-1999              Member, Editorial Board, “African Journal of Neuroscience

1994-1998              Chief Editor, “Metabolic Brain Disease

1994-2004              Assistant Editor, “Addiction Biology

1998-2010              Editor-in-Chief, “Neurochemistry International

1998-present        Associate Editor, “Metabolic Brain Disease

1999-2007              Member, Editorial Board, “Journal of Hepatology

1999-2010              Member, Editorial Board, “International Journal for Developmental Neuroscience

 

SCIENTIFIC ASSOCIATIONS                                                                                                Since:

  1.   The International Society for Hepatic Encephalopathy and Nitrogen Metabolism              1972

                              -    President Elect, 2005

                              -    President, 2009

                              -    Past President, 2011

  1.   The Society of Neuroscience                                                                                                  1976
  2.   The International Society for Neurochemistry                                                                      1980

-          Council member, 1997-2001

-          Treasurer, 2001-2005

-          President Elect, 2005

-          President, 2006-2007

  1.   The American Society for Neurochemistry                                                                                    1981

-          Member, Organizing Committee, Annual Meeting, 1986

-          Member, Neurochemistry and Public Policy Committee, 1987-1990

-          Member, Programme Committee, Annual Meetings, 1993

-          Council member, 1998-2003

  1.   The New York Academy of Sciences                                                                                    1986
  2.   The Canadian Association for the Study of the Liver                                                        1987

-          Member, Governing Board, 1991-1994

-          Secretary/Treasurer, 1999-2003

  1.   The International Society of Cerebral Blood Flow and Metabolism                                          1988
  2.   The American Association for the Study of Liver Disease                                                        1988

-          Member, Program Committee, 1992-1994

 

RESEARCH SUPPORT (from 2005 to 2011)

(a) COMPLETED GRANTS

MOP 15065 (Roger F. Butterworth, PI) 1998-10-01 – 2008-09-30

Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes

Further studies on the pathogenesis of portal-systemic encephalopathy, a major neurological complication of chronic liver failure

MOP 74474 (Roger F. Butterworth, PI) 2005-04-01 – 2008-03-31

Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes

Further studies of vascular factors in the pathogenesis of selective neuronal cell death due to impaired oxidative metabolism

CCI 85676 (Roger F. Butterworth and Liang Peng, PI) 2008-01-01 – 2010-12-31

Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes (China-Canada Joint Health Research Initiative)

Towards a rational therapy for the cerebral complications of liver failure

(b) operating GRANTS

MOP 15065 (Roger F. Butterworth, PI) 1998-10-01 – 2011-09-30

Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes

Further studies on the pathogenesis of hepatic encephalopathy and brain edema, major neuropsychiatric complications of acute liver failure

PRG 80160  (Leonard J. Hoffer, PI) 2006-04-01 – 2011-03-31

Canadian Insitutes of Health Research, Research Resource Grant Program

Mass spectrometry facility maintenance

 


PEER-REVIEWED JOURNALS AND REVIEW ARTICLES (selected from a total of 984)   1997-2019

Raghavendra Rao, V.L., Audet, R.M. and Butterworth, R.F.: Portacaval shunting and hyperammonemia stimulate the uptake of L-3H-arginine but not L-3H-nitroarginine into rat brain synaptosomes J Neurochem 68(1): 337-343, 1997

 

Michalak, A. and Butterworth, R.F.: “Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure” Hepatology 25(3): 631-635, 1997

 

Therrien, G., Butterworth, J., Rose, C. and Butterworth, R.F.: Protective effect of L-carnitine in ammonia-precipitated encephalopathy in portacaval shunted rats: evidence for a central mechanism of action” Hepatology 25(3): 551-556, 1997

 

Mousseau, D.D., Baker, G.B. and Butterworth, R.F.: “Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy” J Neurochem 68(3): 1200-1208, 1997

 

Butterworth, R.F.: “Hepatic encephalopathy and brain edema in acute hepatic failure: Does glutamate play a role?Hepatology 25(4): 1032-1034, 1997

 

Schenker, S. and Butterworth, R.F.: “NMR spectroscopy in portal-systemic encephalopathy: are we there yet?” Gastroenterology 112(5): 1758-1761, 1997

 

Kril, J.J. and Butterworth, R.F.: Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease” Hepatology 26(4): 837-841, 1997

 

Michalak, A., Rose, C., Buu, P.N.T. and Butterworth, R.F.: “Evidence for altered central noradrenergic activity in experimental acute liver failure” Hepatology 27(2): 362-368, 1998

 

Butterworth, R.F.: “Excitatory neurons and schizophrenia” Lancet 352(9141):1643, 1998

 

Todd, K.G. and Butterworth, R.F.: “Early microglial response in experimental thiamine deficiency: An immunohistochemical analysis” Glia 25(2):190-198, 1999

 

Todd, K. and Butterworth, R.F.: “Mechanisms of selective neuronal cell death due to thiamine deficiency” Ann N Y Acad Sci 893: 404-411, 1999

 

Rose, C., Michalak, A., Rama Rao, K.V., Quack, G., Kircheis, G. and Butterworth, R.F.: “L-Ornithine-L-Aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure” Hepatology 30(3): 636-640, 1999

 

Rose, C., Butterworth, R.F., Zayed, J., Normandin, L., Todd, K., Spahr, L., Huet, P.-M., and Pomier Layrargues, G.: “Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction” Gastroenterology 117(3): 640-644, 1999

 

Rose, C, Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A. and Butterworth, R.F.: “Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure” Hepatology 31(4): 872-877, 2000

 

Butterworth, R.F.: “Complications of cirrhosis III. Hepatic encephalopathy” J Hepatol 32(1 Suppl): 171-180, 2000

Lozeva, V., Tuomisto, L., Sola, D., Plumed, C., Hippelainen, M. and Butterworth, R.F.: “Increased density of brain histamine H1 receptors in rats with portacaval anastomosis and in cirrhotic patients with chronic hepatic encephalopathy” J Hepatol 33(6): 1370-1376, 2001

 

Hazell, A.S., Rama Rao, K.V., Danbolt, N.C., Pow, D.V. and Butterworth, R.F.: “Selective downregulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke’s encephalopathy” J Neurochem 78(3): 560-568, 2001

 

Butterworth, R.F.: “Images of the brain in chronic liver failure” J Hepatol 35(5): 661-662, 2001

 

Corbalan, R., Chatauret, N., Behrends, S., Butterworth, R.F. and Felipo, V.: “Region-selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients” Hepatology 36(5): 1155-1162, 2002

 

Butterworth, R.F.: “Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies J Hepatol 39(2): 278-285, 2003

 

Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D. and Butterworth, R.F.: Effects of hypothermia on brain glucose metabolism in acute liver failure: a 1H/13C-nuclear magnetic resonance study” Gastroenterology 125(3): 815-824, 2003

 

Zwingmann, C., Chatauret, N., Leibfritz, D. and Butterworth, R.F.:Selective increase of brain lactate synthesis in experimental acute liver failure: Results of a [1H/13C] nuclear magnetic resonance study Hepatology 37(2): 420-428, 2003

 

Lozeva, V., Tuomisto, L., Tarhanen, J. and Butterworth, R.F.: “Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma” J. Hepatol 39(4): 522-527, 2003

 

Lozeva, V., Montgomery, J.A., Tuomisto, L., Rocheleau, B.,Pannunzio, M., Huet, P-M. and Butterworth, R.F.: Increased Brain Serotonin Turnover Correlates with the Degree of Shunting and Hyperammonemia in Rats Following Variable Portal Vein Stenosis J Hepatol 40(5): 742-748, 2004

 

Butterworth R.F.: “Reply to Dr F. Salerno” J Hepatol 42(3): 423, 2005

 

Ahboucha, S., Pomier-Layrargues, G., Mamer, O. and Butterworth, R.F.: “Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy” Ann Neurol 58(1): 169-170, 2005

 

Bélanger, M., Desjardins, P., Chatauret, N., Rose, C. and Butterworth, R.F.: “Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure” J Hepatol 42(5): 694-699, 2005

 

Vaquero, J., Rose, C. and Butterworth, R.F.: “Keeping cool in acute liver failure: Rationale for the use of mild hypothermia” J Hepatol 43(6): 1067-1077, 2005

 

Bélanger, M., Desjardins, P., Chatauret. N. and Butterworth, R.F.: “Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure (p NA)” Glia 53(5): 557-562, 2006

 

Chatauret, N., Desjardins, P., Zwingmann, C., Rose, C., Rama Rao, K.V. and Butterworth, R.F.: “Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure” J Hepatol 44(6): 1083-1088, 2006

 

Vaquero, J., Bélanger, M., Blei, A.T. and Butterworth, R.F.: “Lack of assessment of body temperature in mice with acetaminophen toxicity” Hepatology 44(1): 279-280, 2006

 

Vaquero, J. and Butterworth, R.F.: “The brain glutamate system in liver failure” J Neurochem 98(3): 661-669, 2006

 

Vaquero, J., Bélanger, M., James, L., Herrero, R., Desjardins, P., Cote, J., Blei, A.T. and Butterworth, R.F.: “Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity” Gastroenterology 132(1): 372-383, 2007

 

Vaquero, J. and Butterworth, R.F.: “Mild hypothermia in the treatment of acute liver failure: what are we waiting for?” Nat Clin Pract Gastroenterol Hepatol 4(10): 528-529, 2007

 

Navarro, D., Zwingmann, C. and Butterworth, R.F.: “Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using (1)H/(13)C NMR spectroscopy J Neurochem 106(2): 603-312, 2008

 

Butterworth, R.F.: “Rifaximin and Minimal Hepatic Encephalopathy” Am J Gastro 106: 317-318, 2011

 

Butterworth R.F, “Hepatic Encephalopathy” in The Liver: Biology and Pathobiology, 5th edition (I. Arias, N. Fausto, Cohen, Shafritz, Alter and J. Boyer, eds.), Raven Press, pp. 595-614, 2009

 

Butterworth, R.F.: “Hepatic encephalopathy” in Metabolic Encephalopathy (D.W. McCandless, ed.), Springer, New York, pp. 149-180, 2009.

 

Butterworth, R.F.: “Hepatic encephalopathy: a primary astrocytopathy” in Astrocytes in Pathophysiology of the Nervous System (V. Parpura, ed.), Springer, New York, pp. 673-692, 2009.

 

Vaquero, J. and Butterworth, R.F.: “Approach to the patient with central nervous system and pulmonary complications of end-stage liver disease” in Principles of Gastroenterology (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp.467-491, 2009.

 

Vaquero, J. and Butterworth, R.F.: “Central nervous system and pulmonary complications of end-stage liver disease” in Textbook of Gastroenterology 5th edition (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp. 2327-2351, 2009.

 

Vaquero, J. and Butterworth, R.F.: “Central nervous system and pulmonary complications of end-stage liver disease” in Atlas of Gastroenterology 4th edition (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp. 698-710, 2009.

 

Jiang, W., Desjardins, P. and Butterworth, R.F.: “Central inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline” J Neurochem 109: 485-493, 2009

 

Jiang, W., Desjardins, P. and Butterworth, R.F.: “Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia” J Cereb Blood Flow Metab 29: 944-952, 2009

 

Sawara, K., Desjardins, P., Chatauret, N., Kato, A., Suzuki, K. and Butterworth, R.F.: “Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure” Neurochem Int 55(1-3): 119-123, 2009

 

Jiang, W., Desjardins, P. and Butterworth, R.F.: “Hypothermia attenuates oxidative/nitrosative stress and brain edema in acute (ischemic) liver failure” Neurochem Int 55(1-3): 124-128, 2009

 

Butterworth, R.F., Norenberg, M., Felipo, V., Ferenci, P., Albrecht, J. and Blei A.T.: “Experimental Models of Hepatic Encephalopathy: ISHEN guidelines” Liver Int 29(6): 783-788, 2009

 

Jiang, W., Desjardins, P. and Butterworth, R.F.: “Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in ratsNeurochem Int 55(7): 601-605, 2009

 

Bémeur, C., Chastre, A., Desjardins, P. and Butterworth, R.F.: “No changes in expression of tight junction proteins or blood-brain barrier permeability in azoxymethane-induced experimental acute liver failure” Neurochem Int 56: 205-207, 2010

 

Bémeur, C., Qu, H., Desjardins, P. and Butterworth, R.F.: “IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure” Neurochem Int 56: 213-215, 2010

 

Bémeur, C., Desjardins, P. and Butterworth, R.F.: “Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy” Metab Brain Dis 25(1): 3-9, 2010

 

Chastre, A., Jiang, W., Desjardins, P. and Butterworth, R.F.: “Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure” Metab Brain Dis 25(1): 17-21, 2010

 

Bémeur, C., Desjardins, P. and Butterworth, R.F.: “Antioxidant and Anti-inflammatory Effects of Mild Hypothermia in the Attenuation of Liver Injury Due to Azoxymethane Toxicity in the Mouse” Metab Brain Dis 25(1): 23-29, 2010

 

Butterworth, R.F.: “MetalToxicity, Liver Disease and Neurodegeneration” Neurotox Res 18(1): 100-115, 2010

 

Bémeur, C., Vaquero, J., Desjardins, P. and Butterworth, R.F.: “N-Acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms” Metab Brain Dis 25(2): 241-249, 2010

 

Butterworth, R.F.: “Altered glial–neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy” Neurochem Int 57: 383-388, 2010

 

Xue, Z., Li, B., Gu, L., Hu, X., Li, M., Butterworth, R.F. and Peng, L.: “Increased Na, K-ATPase alpha(2) isoform gene expression by ammonia in astrocytes and in brain in vivo” Neurochem Int 57: 395-403, 2010

 

Beauchesne, E., Desjardins, P., Butterworth, R.F. and Hazell, A.S.: “Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency”. Neurochem Int 57: 830-837, 2010

 

Dhiman R.K, Saraswat V.A, Sharma B.K, Sarin S.K, Chawla Y.K, Butterworth R.F, et al., Minimal hepatic encephalopathy:Consensus statement of a working party of the Indian National Association for Study of the Liver, J Gastroenterol. Hepatol., 25, 1029-1041, 2010

 

Bémeur, C., Desjardins, P. and Butterworth, R.F.: “Role of Nutrition in the Management of Hepatic Encephalopathy in End-Stage Liver Failure” J Nutr Metab Epub 2011 Dec 22 doi:10.1155/2010/489823

 

Butterworth, R.F.: “Rifaximin and Minimal Hepatic Encephalopathy” Am. J Gastroenterol. 106, 317-318, 2011

 

Bajaj, J., Cordoba, J., Mullen, K., Amodio, P., Shawcross, D.L., Butterworth, R.F. and Morgan, M.Y.: Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement.”, Aliment Pharmacol Ther. 2011 Apr;33(7):739-47

 

Butterworth, R.F.: “Hepatic Encephalopathy: a central neuroinflammatory disorder?” Hepatology 53, 1372-1376, 2011

 

Bémeur, C., Montgomery, J.A. and Butterworth, R.F.: “Vitamin Deficiencies and Brain Function” in Neurochemical Mechanisms in Disease (J. Blass, ed.), Springer Science+Business Media, pp. 103-124, 2011

 

Butterworth R.F.,Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets.”, Neurochem Int. 2011 Nov;59(6):830-6.

 

Chastre A, Belanger M, Beauchesne E, Nguyen BN,Desjardins P and Butterworth RF., “Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications.”, PLoS One 7, e49670, 2012

 

Butterworth R.F.Liver: risk of falls in cirrhosis predicted by psychometric testing.”, Nat Rev Gastroenterol Hepatol. 2012 Feb 21;9(4):197-8

Butterworth R.F., Neuroinflammation in the pathogenesis of hepatic encephalopathy, in “Hepatic Encephalopathy” (Mullen KD and Prakash RK, eds), Clin Gastroenterol, 3, 19-34, 2012  

 

Desjardins P, Du T, Jiang W, Peng L and Butterworth R.F: “Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem. Int., 60, 690-696, 2012

 

Ahboucha S, Talani G, Fanutza T, Sanna E, Biggio G, Gamrani H and Butterworth R.F, Reduced brain levels of DHEAS in hepatic coma patients: Significance for increased GABAergic tone in hepatic encephalopathy, Neurochem Int. 2012 Jul;61(1):48-53

 

Butterworth, R.F.: “Role of Ammonia and Neurosteroids in the Pathogenesis of HE” in Hepatic Encephalopathy (K. Mullen and R. Prakash, eds), Springer Science+Business Media, 2012 

 

José I. Fortea, Javier Vaquero and Roger F. Butterworth. “Clinical and Experimental Relevance of Hypothermia in Acetaminophen Hepatotoxicity.” In Hypothermia: Prevention, Recognition and Treatment, Juan I. Valdez Delgado and Verman G. Fernandez Garza (Eds.) Nova Science Publishers 2012 

Amodio, P., Bémeur, C., Butterworth, R.F., Cordoba, J., Kato, A., Montagnese, S., Morgan, M.M., Uribe, M., Vilstrup, H.The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus.” Hepatology. 2013 Jul;58(1):325-36.

 

Mireille Bélanger, Javier Vaquero, Roger F. Butterworth. Neuroglia in Hepatic Encephalopathy.” In Neuroglia (3rd Edition), Helmut Kettenmann and Bruce R. Ransom (Eds.) Oxford University Press 2013

Bémeur, C. and Butterworth, R.F.: “Thiamin in Modern Nutrition” in Health in Disease, 11th edition (C. Ross, B. Caballero, R. J. Cousins, K. L. Tucker and T. R. Ziegler, eds.), Lippincott Williams & Wilkins, 2013

 

Bemeur C and Butterworth R.F., “Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema, Metab Brain Dis., 28, 145-150, 2013

 

Butterworth R.F, Parkinsonism in cirrhosis: pathogenesis and current therapeutic options, Metab Brain Dis. 2013 Jun;28(2):261-7

 

Butterworth R.F, The liver-brain axis in liver failure: Neuroinflammation and encephalopathy, Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):522-8

 

Chastre A, Belanger M, Nguyen B.N., and Butterworth R.F., “Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure, Liver Int. 2014 Mar;34(3):353-61

 

Thumburu K K, Dhiman R.K, Vasishta E.J, Butterworth R.F et al., “Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure, J Neurochem. 2014 Mar;128(5):617-27.

 

Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF et al., “Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.”, CNS Drugs. 2014 Aug;28(8):679-97

 

Butterworth R.F., “Pathophysiology of brain dysfunction in hyperammonemic syndromes: the many faces of glutamine”, Mol Genet Metab. 2014 Sep-Oct;113(1-2):113-7

 

Butterworth R.F., “Hepatic encephalopathy in alcoholic cirrhosis.”, Handb Clin Neurol. 2014;125:589-602.

 

Bemeur C and Butterworth R.F., “Nutrition in the management of cirrhosis and its neurological complications.”, J. Clin. Exp. Hepatol., 4, 141-150, 2014

 

Butterworth R.F., “Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure.”, J Clin Exp Hepatol. 2015 Mar;5(Suppl 1):S96-S103

 

Butterworth R.F., A Tribute to a Dear Colleague: Joan (Juan) Cordoba 1964-2014, J. Clin. and Exp. Hepatol., 5, 001, 2015.


Butterworth R.F., “Etiology of cirrhosis predicts deterioration of "brain reserve" after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt.” Liver Transpl. 2015 Sep;21(9):1115-6.

 

Butterworth R.F., “Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities.”, J Steroid Biochem Mol Biol. 2016 Jun;160:94-7

 

Butterworth R.F., “The concept of "the inflamed brain" in acute liver failure: mechanisms and new therapeutic opportunities.”, Metab Brain Dis. 2016 Dec;31(6):1283-1287

 

Butterworth R.F., “Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited.”, Metab Brain Dis. 2016 Dec;31(6):1211-1215.

 

Butterworth R.F., Kircheis G, Hilger N, McPhail MJW, “Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials.”, J Clin Exp Hepatol. 2018 Sep;8(3):301-313

 

Butterworth R.F. and Canbay A, “Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease”, Dig Dis. 2019;37(1):63-68

 

Butterworth R.F., “L-Ornithine L-Aspartate (LOLA) for the Treatment of Hepatic Encephalopathy in Cirrhosis: Novel Insights and Translation to the Clinic.”, Drugs. 2019 Feb;79(Suppl 1):1-3

 

Butterworth R.F., “Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology.”, Drugs. 2019 Feb;79(Suppl 1):17-21

 

Butterworth R.F. and McPhail MJW, “L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses.”, Drugs. 2019 Feb;79(Suppl 1):31-37

 

Butterworth R.F., “L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle.”, Can J Gastroenterol Hepatol, vol. 2019, Article ID 8182195, 6 pages, 2019. https://doi.org/10.1155/2019/8182195.

 

Butterworth, R.F. “ L-ornithine L-aspartate for the Treatment of Sarcopenia in Cirrhosis: Potential Impact on the Outcome of Liver Transplantation.” Ann Gastroenterol Dig Dis. 2019, 2(1): 006-009.

Butterworth R.F. “Beneficial effects of L-Ornithine L-Aspartate for prevention of overt hepatic encephalopathy in patients with cirrhosis: a systematic review with meta-analysis.”, Metab Brain Dis 2019, in press

 

Butterworth R.F., “L-Ornithine L-Aspartate: Multimodal Therapeutic agent for Hyperammonemia and Hepatic Encephalopathy in Cirrhosis", J Pharmacol Pharm Res 2019, in press

 

Butterworth R.F. and Gruengreiff K, “L-ornithine L-aspartate for the treatment of hepatic encephalopathy in cirrhosis: evidence for novel hepatoprotective mechanisms.”, JSM Liv Clin Res 2019, in press

 

Butterworth R.F., “Hepatic encephalopathy” in The Liver:Biology and pathobiology, 6th Ed., I Arias, H Alter, J Boyer, D Cohen, S Torgeirsson, D Shafritz, A Wolkoff, Eds, John Wiley &Sons, UK, 2019, in press. 

 

 

 

 

 

 

 

 

 

 

 

 


Presentations as guest speaker 2009-2019

 

Invited speaker, 19th Asian Pacific Association for the Study of the Liver, Hong Kong, China, February 2009

 

Invited speaker, Canadian Digestive Week and 5th Ann ual Canadian Association for the Study of the Liver Winter Meeting, Banff, Canada, February 2009

 

Chair and invited speaker, Colloquium “Why the Brain Fails When the Liver Ails”, 40th American

Society for Neurochemistry Meeting, Charleston, USA, March 2009

 

Invited speaker, “Neurochemical mechanisms of neurodegenerative disorders”, IV Neurotoxicity Society Meeting, Arica, Chile, April 2009

 

Invited speaker, 5th International Hannover Conference on Hepatic Encephalopathy, Hannover, Germany, May 2009

 

Invited speaker, 5th Forum of Hepatic Encephalopathy, Morokia, Japan, August 2009

 

Invited speaker, ISN/APSN 22nd Biennial Congress, Busan, Korea, August 2009

 

Invited speaker, International Symposium on Hyperammonemia and Hepatic Encephalopathy, Valencia, Spain, September 2009

 

Invited faculty and invited speaker, 60th Annual meeting of of the American Association for the Study of the Liver (AASLD), Boston, USA, November 2009

 

Organizer and invited faculty, ISN-IBRO Neuroscience School, Fayoum, Egypt, December 2009

 

Invited speaker, 9th International Society of Neuroscientists of Africa Conference, Sharm-el-Sheikh, Egypt, December 2009

 

Research seminar, Institut de Recerca, Liver Unit, Hospital Vall Hebron, Barcelona, Spain, March 2010.

 

Research seminar, Liver Unit, Hospital Clínic de Barcelona, Barcelona, Spain, March 2010.

 

Invited speaker, EASL-ISHEN joint workshop “Hepatic Encephalopathy: New Therapies and New Trials”, International Liver Congress (EASL), Vienna, Austria, April 2010.

 

Invited speaker, Merz Satellite Symposium “Minimal Hepatic Encephalopathy – a Significant Complication of Cirrhosis”, International Liver Congress (EASL), Vienna, Austria, April 2010.

 

Invited faculty, Gastroenterology Course “Challenges in diagnostics and therapies in gastroenterology and hepatology”, INCMNSZ Hospital, Mexico, Mexico, July 2010.

 

Invited speaker, Ditan International Conference on Infectious Diseases (DICID), Beijing, China, July 2010.

 

Invited speaker, GIGA, University of Liege, September 2010.

 

Invited speaker, British Association for Study of the Liver Annual Meeting, Edinburgh, U.K., September 2010.

 

Organizer /Speaker, 14th ISHEN Symposium, Val-David, Canada, September 2010.

 

Invited Speaker, British Gastroenterology Society meeting, Birmingham, UK, 14-17 March 2011.

 

Invited Speaker, Indian Association for the Study of the Liver, Chandigarh, India, 24-27 March, 2011.

 

Invited Speaker, EASL-ISHEN Workshop on Hepatic Encephalopathy, Berlin, Germany, 30 March, 2011.

 

Invited Speaker, EASL-Merz Workshop on Pre/Post-OLT Neurological Symptoms in Cirrhosis, Berlin, Germany, 2 April, 2011.

 

Invited Speaker, Transplant Center Grand Rounds, Mayo Clinic, Florida, USA, 30 June, 2011.

 

Invited Speaker, Brazilian Congress of Hepatology, Bahia, Brasil, July, 2011

 

Invited Speaker, Transplant Grand Rounds, University of Iowa, Iowa, USA, September , 2011

 

Plenary Lecture, 15th ISHEN Symposium, Aarhus, Denmark, May 2012

 

Invited Speaker, Transplant Grand Rounds, University of Idaho, Nebraska, USA, June 2012

 

Opening Lecture, Japanese Digestive Diseases Week (JDDW), Kobe,Japan. October 2012

 

“The Andy Blei Lecture”, 16th ISHEN Symposium, London, UK, May 2014

 

Invited Speaker, 8th International Conference on thiamine: from catalysis to pathology, Liege, Belgium, May, 2014

 

Invited Speaker, International Gastroenterology Summit meeting, Luxor, Egypt, February, 2015

 

Invited Speaker, 8th International Meeting: Steroids and the Nervous System, Torino, Italy, February 2015

 

Invited Speaker, 17th ISHEN Symposium, Delhi, India, March 2017

 

Invited speaker/Chair, Merz Satellite Symposium “New dimensions in the treatment of chronic liver diseases and hepatic encephalopathy”, International Liver Congress (EASL), Vienna, Austria, April 2019.

 

Invited Speaker, 18th ISHEN Symposium, Williamsburg, VA, USA, September 2019