Richard Todd Stravitz, MD
Disclosures: Nothing to disclose
CURRICULUM VITAE

 

 

CURRICULUM VITAE

 

Updated: May, 2019

 

PERSONAL INFORMATION

 

Name:               Richard Todd Stravitz, M.D., F.A.C.P., F.A.C.G., F.A.A.S.L.D.

 

Title:                                                        Professor of Medicine (Tenured)

 

Business Address:               Section of Hepatology

                                                        Division of Gastroenterology, Hepatology and                                                                                                   Nutrition

                                                        Medical College of Virginia of

                                                                      Virginia Commonwealth University

                                                        1200 East Broad St.

                                                        PO Box 980341, MCV Station

                                                        Richmond, VA 23298-0341

 

Research Facility:                            Virginia Commonwealth University

                                                        1300 East Marshall St.

                                                        Clinical Research Services Unit

                                                        North Hospital; 8th Floor

                                                        Richmond, VA 23298

 

                                       VCU Medical Center Investigational Drug Service

                                       Main Hospital, Basement, B-300

                                       401 North 12th Street

                                       P. O. Box 980042

                                       Richmond, VA  23298-0042                

 

Business Telephone:              (804) 828-9311

Business Fax:                            (804) 828-4995

Business E-mail:                            Richard.Stravitz@VCUHealth.ORG

 

 

PROFESSIONAL SUMMARY

 

Primary Departmental Program Area: Hepatology; Liver Transplant Program

 

Areas of Expertise and Interest:

              Cirrhosis and liver failure

              Liver transplantation

              Living donor liver transplantation

              Acute liver failure

              Hepatocellular carcinoma

              Viral hepatitis

              Autoimmune hepatitis

              Hyperlipidemia

 

Research Training Certificates:

 

    CITI: Collaborative Institutional Training Initiative (completed 10/25/15)

        · Biomedical Basic Human Subjects Research Exp. 10/25/17

        · Biomedical Refresher Human Subjects Research Exp. 10/25/17

        · Biomedical Responsible Conduct of Research (RCR) Exp. 10/25/17

        · Good Clinical Practice (GCP) (completed 12/5/2009, no expiration).

 

EDUCATION

 

              Postgraduate:

                            Hepatology/Liver Transplantation Fellowship 1996-7

                            Hume-Lee Transplant Center of

                                          Virginia Commonwealth University

                            Richmond, VA 23298

 

                            Gastroenterology Fellowship 7/1990-6/1993

                                          Research Fellow 7/1991-6/1993

                                          Clinical Fellow 7/1990-6/1991

                                          Chief Fellow 7/1992-6/1993

                            Virginia Commonwealth University Medical Center and

                            H.H. McGuire Department of Veterans Affairs Medical Center

                            Richmond, VA 23298

 

                            Chief Medical Resident 7/1989-6/1990

                            Wake Medical Center and

                            North Carolina Memorial Hospital

                            University of North Carolina

                            Chapel Hill, NC 27514

 

                            Internal Medicine Internship and Residency 7/1986-6/1989

                            North Carolina Memorial Hospital

                            University of North Carolina

                            Chapel Hill, NC 27514

 

              Graduate:             

                            New York University School of Medicine, 9/1982-6/1986

                            New York, NY 10016

                            M.D. June, 1986

 

              Undergraduate:

                            College of William and Mary, 9/1979-6/1982

                            Williamsburg, VA 23185

                            B.S. May, 1982; Major in Biology

                            Phi Beta Kappa (Alpha Chapter)

                           

 

CERTIFICATION AND LICENSURE

 

              Licenses and Registration:

                            North Carolina, 1989-1991

                            Virginia, 1990-present

                            DEA Registrant BS3298329

                                                                     

              Certification:             

                            ABIM/Internal Medicine, 1990

                            ABIM/Gastroenterology, 1995

                                          Recertification in Gastroenterology, 2005

                                          Recertification in Gastroenterology, 2015

                            ABIM/Hepatology and Liver Transplantation Certificate of                                                                       Added Qualification, 2006

 

              Hospital Appointments:

                            Attending Physician

                            Virginia Commonwealth University Medical Center

                            Richmond, VA

 

                            Attending Physician

                            H. H. McGuire Department of Veterans Affairs Medical Center

                            Richmond, VA

 

ACADEMIC APPOINTMENT HISTORY

 

DATES                                          RANK                                                                      INSTITUTION

 

7/2018-present*              Professor of Medicine                             Virginia Commonwealth                                                         with Tenure                                                                      University

                                                                                                                Richmond, VA 23298

 

10/2009-6/2018*              Professor of Medicine                            Virginia Commonwealth                                                                                                                                             University

                                                                                                                Richmond, VA 23298

 

11/2000-9/2009*              Associate Professor of Medicine              Virginia Commonwealth                                                                                                   University

                                                                                                                Richmond, VA 23298

                                         

7/1993-3/1999*              Assistant Professor of Medicine              Virginia Commonwealth                                                                                                                                             University

                                                                                                                Richmond, VA 23298

 

7/1992-6/1993*              Instructor in Medicine                            Virginia Commonwealth                                                                                                                                             University

                                                                                                                Richmond, VA 23298

 

*Section of Hepatology, Division of Gastroenterology, Department of Internal Medicine; Virginia Commonwealth University.

 

                           

EMPLOYMENT HISTORY AND WORK EXPERIENCE

 

DATES                                          TITLE                                                                      INSTITUTION

 

6/2009-Present              Medical Director of Liver                             Virginia Commonwealth

                                          Transplantation                                                        University

                                                                                                                Richmond, VA 23298

 

7/2006-6/2008              GI Fellowship Director                            Virginia Commonwealth                                                                                                                                             University

                                                                                                                Richmond, VA 23298

 

11/2000-Present              Staff Physician                                          Virginia Commonwealth

                                                                                                                              University

                                                                                                                Richmond, VA 23298

 

3/1999-11/2000              Staff Physician                                          Virginia Physicians

                                          GI Division                                                        Richmond, VA

 

7/1993-Present              Staff Physician                                          McGuire Veteran’s Affairs

                                                                                                                Medical Center

                                                                                                                Richmond, VA

 

 

SPECIAL AWARDS AND HONORS

 

              Burton Combes Memorial Lectureship, University of Texas, Southwestern                                           Medical School, Dallas, TX; August, 2019.

              Cecil J. Watson Memorial Lectureship, University of Minnesota,                                                         Minneapolis, MN; May, 2018.

              Andres T. Blei Memorial Lectureship, Feinberg School of Medicine,                                                         Northwestern University, Chicago, IL; March, 2014.

              Richmond Magazine, “Top Docs,” 2012, 2013

              VCU School of Medicine Outstanding Teacher Award, 2007

              VCU Department of Internal Medicine Faculty Award for Distinguished                                           Research, 2006

              Glaxo Institute for Digestive Health Basic Research Award, 1994

              Phi Beta Kappa (Alpha Chapter), 1982

              Phi Sigma Outstanding Senior Biologist, 1982

              M.E. Ferguson Memorial Research Grant, 1982

              Phi Sigma (Biology Honor Society), 1981

 

 

MEMBERSHIP IN SCIENTIFIC OR PROFESSIONAL SOCIETIES

 

              American College of Gastroenterology (2007-present)

                            Election to Fellowship 2007

              American College of Physicians (1991-present)

                            Election to Fellowship 2000

              American Gastroenterological Association (1996-present)

              American Association for the Study of Liver Diseases (1997-present)

                            Election to Fellowship 2016

              International Liver Transplant Society (2001-present)

              Richmond Academy of Medicine (1999-present)

              Virginia Medical Society (2000-present)

              American Society of Transplantation (2004-present)                           

             

 

SCIENTIFIC AND SCHOLARLY ACTIVITIES

 

EXPERT SERVICES

Journals:

              Editorial Board, Hepatology, 2017-2019

              Associate Editor, Journal of Hepatology, 2015-2017 and 2017-2019 (2                                           terms to end December 31, 2019)

              Editorial Board, World Journal of Gastroenterology, 2008-2011

              Abstract Reviewer, American Transplant Congress, 2006-2014

              Abstract Reviewer, American Association for the Study of Liver Disease,                                           1997-1998, 2007-present

              Journal Referee, Gastroenterology, American Journal of Gastroenterology,                                           Liver Transplantation, Scandinavian J. Gastro., Clinical                                                         Gastroenterology, Hepatology, Journal of Lipid Research,                                                         Hepatology, Alimentary Pharmacology and Therapeutics, Am J                                           Gastroenterology, J Hepatology, Liver International, Journal of                                           Pediatrics

 

Visiting Professorships:

              University of Texas, Southwestern, Dallas, TX; August, 2019

              University of Minnesota, Minneapolis, MN; May, 2018

              University of Alberta, Edmonton, Canada; March, 2017

              University of Calgary, Alberta, Canada; March, 2017

              Medical University of South Carolina, Charleston, SC; January, 2015

              Ohio State University, Columbus, OH; December, 2014

              Northwestern University, Chicago, IL; March, 2014

              University of Chicago, Chicago, IL; November, 2013

              Mayo Clinic/Scottsdale, Scottsdale, AZ; May, 2013

              University of Pennsylvania, Philadelphia, PA; January,               2013

              Mayo Clinic Foundation Center for Research in Digestive Diseases,                                                         Rochester, MN; September, 1996.

 

Other:

              Scientific Advisory Committee, International Coagulation in Liver Disease                                           Study Group, 2015

              Data Safety Monitoring Board, Hyperion Pharmaceuticals, 2007-2008

                           

                                         

GRANTS AND CONTRACTS

             

              Active Grants:

                            “A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-                                          002 (ornithine phenylacetate) in the Treatment of Patients with                                           Acute Liver Failure due to Acetaminophen Overdose (STOP-ALF).”

                            Ocera Therapeutics. RTS, co-PI.

                           

A Multi-Center Group to Study Acute Liver Failure.” Acute Liver Failure Study Group, NIH/NIDDK 2U01DK058369-16. RTS, Co-P.I. 25% effort. Total Award: $3,475,240 09/01/2000 – 08/31/2020.

 

              Submitted/Pending Grants:

                            “A Phase 2 Evaluation of the AcetaSTAT adduct Lateral Flow Assay                                           for the Diagnosis of Acetaminophen Toxicity.” Acetaminophen                                           Toxicity Diagnostics, LLC (ATD), sponsor; Laura P. James                                                         (University of              Arkansas), PI; RTS sub-PI.

 

              Past Grants:

“Adduct Dipstick for the Diagnosis of Acetaminophen Toxicity.” NIDDK #2R42DK079387-03; Laura P. James (University of Arkansas), PI; RTS sub-PI.

 

“Adult-to-adult living donor liver transplantation study group” (“A2ALL”). RTS, co-P.I., 10% effort; R.A. Fisher, P.I.. NIH/NIDDK 1U01DK62531-01 9/1/02-8/31/15.

 

                            A Phase 2, Multicenter, Open-Label Study to Investigate the

                            Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose

                            Combination + Ribavirin Administered in Subjects Infected

                            with Chronic HCV who have Advanced Liver Disease or are

                            Post-Liver Transplant. Sponsor: Gilead Sciences, Inc. RTS, site PI.                                           $55,960 (2013-2014).

 

PLT-BID-1108 12/1/09 – 11/30/12 Exalenz Bioscience, Inc.

Use of the Exalenz Methacetin Breath test to assess Hepatic Metabolic Reserve and to Predict Hepatic Decompensation in Patients with Cirrhosis Awaiting Liver Transplantation.

Role: PI

 

                            “Probiotic Yogurt for the Treatment of Minimal Hepatic                                                         Encephalopathy.” 1U1AT004428-01A1 / PT104399 (Bajaj)                                                        (RTS, co-PI). 8/30/09 – 8/31/12.             

 

                            U01DK062531 9/1/09 – 8/31/10NIH/NIDDK

                            The A2ALL LADR Protocol Pre-transplant Treatment to Prevent                                           Recurrence of Hepatitis C after Living Donor Liver Transplantation

                            Role: Sub-Project PI

 

“N–Acetylcysteine for acute liver failure other than acetaminophen overdose.” RTS site P.I.; W.M. Lee, P.I. NIH/NIDDK 5R01 DK 58369. 9/1/2000-10/31/07.

 

                            “A Phase-II, Multicenter, Randomized, Open-Label, Dose-Ranging,                                           Parallel Group Study of the Anti-Viral Effects, Pharmacokinetics and                             Safety of HEPEX-B as Compared to Hepatitis B Immune Globulin in                                           Patients who have Received Hepatic Allografts for Hepatitis B Virus                                           Infection.” XTL BioPharmaceuticals, Inc. RTS, site-P.I., 15% effort,                                           11/1/2004–10/31/2005.

 

                            Glaxo Institute for Digestive Health Basic Research Award, 1994.                                           “Regulation of cholesterol 7α-hydroxylase by bile acids and                                                         cholesterol.” RTS, P.I., ($40,000).

 

                            “Regulation of cholesterol 7α-hydroxylase.” NIH PO 1 Z. Reno                                           Vlahcevic, PI; RTS co-investigator. 7/1/1997-6/30/2002.

 

                            "Regulation of cholesterol 7α-hydroxylase by bile acids and cholesterol." Merit Review Award, Veterans Health Services and Research Administration. RTS, P.I. ($393,000). 10/1/1995-9/30/1999.

             

"Regulation of cholesterol 7α-hydroxylase by bile acids and cholesterol." Research Associate Award, Career Development Program, Veterans Health Services and Research Administration. RTS. P.I. ($500,000). 7/1/1995-6/30/1999.

                           

                            "Regulation of bile acid synthesis in primary hepatocyte cultures."                                           Associate Investigator Award, Career Development Program,                                           Veterans Health Services and Research Administration.                                                          ($146,500), 7/1/1992-6/30/1995.                            

             

              Research Advising and Mentoring             

                           

                            Resident physicians:

                                          Thure Caire, MD: “CBC predictors of outcome after acute                                                                       liver failure.” 2012-3 (manuscript in preparation,                                                                       2015)

                                          Grant Farr, MD: “Use of thromboelastography to predict                                                                       complications and outcome of cirrhosis.” 2012

                                          Anna Beth Barton, MD: “Optimized treatment of low bone                                                                       mineral density in patients with cirrhosis.” 2012

                                          Tahir Shaikh, DO: “Safety and tolerance of sirolimus in liver                                                                       transplant recipients.” 2008. (Oral presentation,                                                                       American Transplant Congress Meeting, 2008).

                                          Daniel Culbert, MD: “Predictors of response to antiviral                                                                       therapy for recurrent hepatitis C in liver transplant                                                                       recipients.” 2008.

 

                            Gastroenterology Fellows:

                                          Brian Davis, M.D.: “Prediction of outcome of acute liver                                                                       failure by the factor VIII/V ratio.”

                                          Kavish Patidar, M.D.: “Investigation of hemostasis in acute-                                                                      on-chronic liver failure by thromboelastography.”                                                                       2017.

                                          Nisha Chand, M.D: Surveillance for hepatocellular                                                                                     carcinoma in patients with cirrhosis improves                                                                                     outcome.” 2007. (Published, Am J Med. 2/2008).                                                        Joseph Beets, MD: “Induction of apical sodium-dependent                                                                       bile acid transporter mRNA, protein, and activity in rat                                                         ileum by intestinal cholic acid.” 1996. (Published                                                                       Gastroenterology, 1996).

                                          W. Andrew Hackworth, MD: “Impact of spontaneous                                                                                     hyponatremia and its correction on outcome after                                                                       orthotopic liver transplantation.” 2007. (Oral                                                                                     presentation, ATC Meeting 2007, with Trainee                                                                                     Research Award. Published Liver International, 2010).

 

                            Transplant Hepatology Fellows:

                                          M. Shadab Siddiqui, MD; Associate Professor, VCU

                                          Scott Matherly, MD; Assistant Professor, VCU

                                          Amon Asgharpour, MD; Assistant Professor, Mount Sinai                                                                       School of Medicine

                                          Narayan Dharel, MD; private practice, Fredericksburg, VA

                                          Kavish Patel, MD; Assistant Professor, Indiana University

 

                            Graduate student:

                                          Trang Nguyen, M.S. Graduate student 1995-7.                                                                                                   Transcriptional regulation of the cholesterol 7α-                                                                      hydroxylase gene by protein kinase C.

             

                            Post-doctoral student:

                                                        Seema Gupta, Ph.D. 1997-9. “Hepatocellular signals                                                                                     regulating cholesterol metabolism.” (Multiple                                                                                     publications-see below).

                           

 

EXTRAMURAL PRESENTATIONS.

             

              Visiting Professorships:

University of Texas, Southwestern Medical Center, Dallas, TX; August, 2019

University of Minnesota; Minneapolis, MN; Cecil Watson Lecture; May, 2018.

University of Calgary; Calgary, Alberta, Canada; March, 2017

University of Alberta; Edmonton, Alberta, Canada; March, 2017

Medical University of South Carolina, Charleston, SC; January, 2015

Ohio State University, Columbus, OH; December, 2014

Northwestern University, Chicago, IL; Andres Blei Memorial Lecture, March, 2014

University of Chicago, Chicago, IL; November, 2013

Mayo Clinic, Scottsdale, AZ; May, 2013

University of Pennsylvania, Philadelphia, PA; January, 2013

Mayo Clinic, Rochester, MN 1996

             

              Local/Regional Presentations:

“Acute Liver Failure 2018: Dissection of a Case.” VCU Division of Transplantation               Surgery Grand Rounds, October 18, 2018.

“Liver Transplantation: 2017 and Beyond.” Hume-Lee Transplant Center’s 60th               Anniversary Symposium, December 2, 2017.

“Update on Living Donor Liver Transplantation.” VCU Transplant Grand Rounds,               November 16, 2017

“Management of the patient with acute liver failure during liver transplantation.”               VCU Department of Anesthesiology Grand Rounds, September, 2016.

“Intensive care management of the patient with acute liver failure.” VCU Division               of Pulmonary Medicine and Critical Care Grand Rounds; August, 2016.

“Non-invasive assessment of liver fibrosis and function: beyond the needle.” VCU Department of Internal Medicine Grand Rounds. March, 2016.

“Difficult cases in patients with liver failure.” Virginia Liver Symposium,               Richmond, VA; March, 2014, 2015, 2016.

“Hemostasis in Liver Disease: a tendency to clot or bleed”? Grand Rounds,               Division of Gastroenterology, Hepatology, and Nutrition, VCU, Richmond,               VA; May 2014

“Cholestatic Liver Disease.” Virginia Chapter, American College of               Gastroenterology, Williamsburg, VA; September, 2013.

“Drug-induced liver injury.” Virginia Liver Symposium, Richmond, VA;                             March, 2013.

“Hemostasis in patients with acute and chronic liver disease: mechanisms               of re-              balance.” Department of Internal Medicine Grand Rounds, Virginia               Commonwealth University,              Richmond, VA; February, 2013             

“Coagulation defects in liver disease.” Virginia Liver Symposium, Richmond, VA;               March, 2012

“Medical Management of the Liver Transplant Recipient.” Medical University of               South Carolina, Charleston, SC; February, 2011.

“Non-invasive assessment of liver fibrosis.” Medical University of South               Carolina, Charleston, SC; February, 2011.

“Pitfalls in the management of chronic liver disease.” Virginia Chapter, American               College of Gastroenterology Meeting, Williamsburg, VA, September, 2010. “Acute liver failure: etiologies and treatment.” Virginia Liver Symposium,               Richmond, VA; February, 2009.             

“Update on chronic hepatitis.” Virginia Chapter, American College of                             Gastroenterology, Williamsburg, VA; September, 2008.                           

“Intensive care of patients with acute and chronic liver failure.” 4th Annual               Neurology Symposium, University of Virginia, Charlottesville, VA. May,               2008.

“Liver transplantation: a life-saving trade of one disease for another.” Eighth               Annual Gastroenterology Symposium, Baptist Health South Florida, Miami,               FL. April, 2008.

Management of hepatitis B before and after liver transplantation.                                           Virginia Liver Symposium, Richmond, VA; February, 2008.

“Recurrence of primary liver disease after Liver Transplantation.” VCU Division of                Transplantation Surgery Grand Rounds, Richmond, VA; May, 2007.

“Recurrent disease after liver transplantation.” Annual meeting of the               Southeastern Foundation for Transplantation (The Transplantation               Foundation), Charlotte, NC; April, 2007.

“Liver transplantation for hepatocellular carcinoma.” Annual meeting of the               Southeastern Foundation for Transplantation (The Transplantation               Foundation), Charlotte, NC; April, 2007.

“The new genetics of Wilson’s Disease.” Virginia Liver Symposium,                                           Richmond, February, 2007. “Liver transplantation for the common man.” Virginia Chapter, American College of Gastroenterology, Williamsburg, VA;               September, 2006.

“Non-cirrhotic portal hypertension.” Virginia Liver Symposium, Richmond, VA;               March, 2005.

“Liver transplantation, 2005: indications and innovations in the MELD era.”               Eastern Virginia School of Medicine, Internal Medicine Grand Rounds.               January, 2005 (televised).

“Pathogenesis and management of hepatic encephalopathy.” VCU Division of               Transplant Surgery Grand Rounds, Richmond, VA; August, 2004.

“Hypercholesterolemia: it’s really a liver disease.” Virginia Liver Symposium,               Richmond, VA; March, 2004.

“Banding for treatment and prophylaxis of esophageal varices.” Virginia Liver               Symposium, Richmond. March, 2003.

“Hepatic manifestations of alpha-1-antitrypsin deficiency.” Virginia Liver               Symposium, Richmond, VA; March, 2002.

“The liver in systemic autoimmune disease.” Virginia Liver Symposium,               Richmond. March, 2001.

“Hepatitis: Ask the Doctor.” WRVA 1140 AM. December, 1999.

“Hepatitis C and HIV co-infection.” Virginia Liver Symposium, Richmond, VA;               March, 1999.

“HCV in Extrahepatic Disease: Scourge or Scapegoat?” Department of Internal Medical Grand Rounds, VCU Medical Center, Richmond, VA; August, 1998.

“Extrahepatic manifestations of chronic hepatitis.” Virginia Liver Symposium, Richmond, VA. March, 1998.

“SBP: Spontaneous Seeding of Susceptible Ascites.” Medical Grand Rounds, H.H. McGuire Veteran’s Affairs Medical Center, September, 1996.

“Regulation of bile acid biosynthesis.” Virginia Chapter, American College of Gastroenterology, Williamsburg, VA; March, 1993.

 

              National Presentations:

“Hemostasis in ALF.” Acute liver failure: science and practice. UT               Southwestern/NIDDK/AASLD Symposium. Dallas, TX; March 31, 2020.

“Coagulation, bleeding complications, and inflammation in ALF: a prognostic               triad.” AASLD/NASPGHAN Pediatric Symposium. Boston, MA; November 8,               2019.

“Coagulation disturbances in cirrhosis.” National Liver Conference. San Antonio,               TX. October 25, 2019.

Management of bleeding & thrombotic complications in the cirrhotic patient.”               Sherilyn Gordon-Burroughs State-of-Art-Lecture. 2019 Emerging Topics               in Liver Disease Conference. Sherrie and Alan Conover Center for Liver               Disease & Transplantation, Houston Methodist; Houston, TX; September               7, 2019.

“Bleeding and thrombosis in patients with liver disease.” Burton Combes Annual               Lecture. University of Texas, Southwestern Medical Center, Dallas, TX;               August, 2019.

“Urgent management of ALF within the first 48 hours.” Digestive Diseases Week               (AGA) Clinical Symposium: Management of acute and acute-on-chronic               liver failure: The first 48 hours. May 20, 2019; San Diego, CA

“Acute Liver Failure, 2019.” Advances in Pulmonary and Critical Care Medicine.               INOVA Farifax, March, 2019; Fairfax, VA.

“Coagulation Disturbances in Cirrhosis.” National Liver Conference. September               21, 2018; Austin, TX.

“Hemostasis in Liver Disease.” University of Minnesota, Minneapolis, MN; May,               2018.

“Acute Liver Failure: Update on Management.” GI Grand Rounds, University of               Minnesota; May, 2018.

“Coagulation derangements in cirrhosis – a new paradigm.” AASLD Postgraduate               Course, Washington DC; October, 2017.

“Coagulopathy in liver disease-monitoring, therapies, and indications for blood               products.” AASLD Acute-on-Chronic Liver Failure Special Interest Group               program, “Management of the critically-ill cirrhotic patient.” Washington,               DC; October, 2017

“Management of acute liver failure.” Emerging Topics in Liver Disease, Houston               Methodist Transplant Center, Houston, TX; September, 2017.

“Coagulopathy in liver disease.” AASLD Clinical Hepatology Update.               San Diego,               CA; June, 2017.

“Thrombosis and coagulopathy in the liver transplant candidate and recipient.” AASLD Liver Transplantation and Surgery Special Interest Group program “Liver Transplantation in the High MELD Era: Perioperative Management of the Critically Ill Patient.” AASLD Annual Meeting, Boston, MA; November, 2016

The BreathID 13C-Methacetin Breath Test (MBT) correlates well with degree of liver disease severity in patients with NASH. NASH Biomarker Meeting, 2016.

“Functional liver testing: Methacetin Breath Test.” Fourth Intermountain West Hepatology Update, Salt Lake City; March, 2016.

“Acute liver failure of undetermined etiology in adults.” National Institutes of Health Clinical Research Workshop in Pediatric Acute Liver Failure of Undetermined Cause. Bethesda, MD; October, 2015. (Meeting Report: Alonso, EM, Horslen, SP, Behrens, EM, Doo, E. Hepatology. 2017; 65: 1026-1037).

“Hemostasis in liver disease: proposed management.” Emerging Topics in Liver               Disease, Houston Methodist Transplant Center, Houston, TX; September,               2015.

“Coagulopathy in liver disease.” 44th Critical Care Congress, Society of Critical               Care Medicine, Phoenix, AZ; January, 2015

“Bleeding in Liver Disease.” Early Morning Workshops at the AASLD                             Annual Meetings: 2011, 2012, 2013, 2014.

“Hemostasis in acute and chronic liver disease: Mechanisms of Re-Balance.”               Invited lecture: Thrombosis and Hemostasis Summit of North America,               Chicago, IL; April, 2014

“Biopsy versus non-invasive approaches to assessing liver fibrosis.” AASLD               Hepatology Associates Course, Washington, DC; November, 2013

“Hemostasis in acute liver failure.” AASLD Emerging Trends in Coagulation               and Anti-coagulation in Liver Disease. AASLD Annual Meeting, Boston, MA               November, 2012

“Coagulopathy in patients with acute liver failure.” AASLD Clinical Symposium,               Digestive Disease Week, San Diego, CA; May, 2012.

“Cerebral edema in toxin-associated acute liver failure.” Meeting of the American               College of Medical Toxicology, Washington, DC; September, 2011.

“Evaluation of a potential donor for living donor liver transplantation.” AASLD               Postgraduate Course, AASLD Annual Meeting, Boston, MA; October, 2009.

“Management of Acute Liver Failure.” AASLD Early Morning Workshops, AASLD               Annual Meeting, Boston, MA; November, 2009, 2010, and 2011.

Management of Acute Liver Failure.” Meet-the-Professor Luncheon, Digestive               Diseases Week, Chicago, IL; June, 2009.

“ICU Management of Acute Liver Failure.” AASLD Clinical Symposium, Digestive               Diseases Week, Chicago, IL; June, 2009.

“Hypothermia for acute liver failure.” Fifth annual meeting of the Neurocritical               Care Society, Las Vegas, NV; November, 2007.

“Autoimmunity in acute liver failure: Can autoimmune hepatitis be distinguished               from indeterminate etiologies?” NIH Acute Liver Failure Workshop,               Bethesda, MD. December, 2006. (Meeting report: Lee, WM, et al. Acute               Liver Failure: Summary of a workshop. Hepatology. 47: 1401-1415, 2008).

“Acute liver failure.” AASLD and ABIM Certificate of Added Qualification in Liver               Transplantation Board Review Course, Chicago, IL; September, 2006.

“Management of hepatic encephalopathy.” Postgraduate Course, Annual Meeting               of the American College of Gastroenterology, Las Vegas, NV; October               2001.

“Role of protein kinase C in transducing bile acid signals to the cholesterol 7α-              hydroxylase promoter.” Division of Gastroenterology Grand Rounds, Mayo               Clinic, Rochester, MN; September, 1996.

 

              International Presentations:

 

“Management of the brain in critical care settings.” International Society for               Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN). September 13,               2019; Williamsburg, VA.

“Incidence of bleeding and thrombosis in acute liver failure: Magnitude of the               Clinical Problem.” 8th International Symposium on Coagulation in Liver               Disease. September 27-28, 2019. Groningen, The Netherlands.

"Coagulopathy in Cirrhosis". Canadian Association for the Study of the               Liver/Association Canadienne pour L’étude du Foie. Single topic               conference: Decompensated Cirrhosis: from Clinic to Transplant. October               13, 2018; Ottawa, ON, Canada.

“Management of haemostasis in acute liver failure before and during liver               transplantation.” Italian Association for the Study of the Liver (AISF).               Sapienza University of Rome, Italy; February, 2016.

“Clinical manifestations of abnormal hemostasis in acute liver failure.” Sixth               International Symposium on Coagulation Defects in Liver Disease,               Charlottesville, VA; October, 2015.

“Understanding and managing coagulopathy in liver failure.” 38th Annual King’s               College Liver Course, London, UK May, 2014.

“Mechanisms of re-balanced hemostasis in acute liver failure.” Fifth International               Symposium on Coagulation Defects in Liver Disease. Padua, Italy;               September,               2013

“Evaluation of hemostatic balance in acute liver failure.” Fourth International               Symposium on Coagulation Defects in Liver Disease, London, UK,               September,               2011.

“Coagulation abnormalities in Acute Liver Failure.” Third International               Symposium on Coagulation Defects in Liver Disease. Groningen, The               Netherlands, September,               2009.

Bleeding complications in patients with acute liver failure requiring intracranial               pressure monitoring.” Second International Symposium on Coagulation               Defects in Liver Disease. Charlottesville, VA. September, 2007.

Signal transduction pathways regulating cholesterol 7α-hydroxylase mRNA levels               by bile acids.” International Bile Acid Meeting, Titisee, Germany; October,               1998.

“Induction of ileal bile acid transporter expression by intestinal bile acids in the               rat.” International Bile Acid Meeting, Freiburg, Germany; October, 1996. “Regulation of cholesterol 7α-hydroxylase by phosphorylation.” International Bile               Acid Meeting, San Diego, CA. October, 1994.

“Regulation of hepatic 3α-hydroxysteroid dehydrogenase.” International Bile Acid               Meeting, Basel, Switzerland. October, 1992.

             

 

TEACHING, ADVISING AND MENTORING.

             

              GI Fellowship Director, 2006-2008. Mentoring and advising duties include residents (5/year) in VCU Department of Internal Medicine, as well as GI Fellows (10/year). Other duties include recruiting and interviewing fellow applicants from >300/year, fellow evaluations, curriculum development, etc.

             

              Mentoring of residents, fellows, graduate and post-graduate students (see list, above).

 

              MII GI Curriculum (diarrhea and hereditary/vascular diseases of the liver). 1-2 contact hours/year.

 

              GI Physiology Seminars, coordinator, 1993-1996.

 

              GI Journal Club, coordinator, 1996-1999.

 

              Physical Diagnosis (MII students), 1993-1996.

 

              Internal Medicine Residency Core Curriculum (acute liver failure, ascites, chonic hepatitis B/C, management of chronic liver failure). 3-4 contact hours/year.

 

              Board review course for VCU internal medicine residents, 2-3 contact hours/year.

             

              Board Review Course for Gastroenterology/Hepatology. I was a faculty member for the William Steinberg GI Board Review Course between 2006-2015. The target audience is first-time, ABIM-Board Eligible GI fellows, and gastroenterologists studying for the re-certifying exam, and is the largest one of its kind in the US, with 300-400 participants/year. I gave 4 lectures a year: Portal Hypertension-GI Bleeding; Portal Hypertension-Other Complications; Liver Transplantation; and, Board Review Questions and Answers for Hepatology.

 

              Board Review for ABIM Certificate of Added Qualification (CAQ) in Liver Transplantation. The target audience is ABIM Board-Certified Gastroenterologists who took the first CAQ exam in Liver Transplantation. Topic: Acute Liver Failure.

 

              Gastroenterology Fellowship Core Curriculum (acute liver failure, hepatocellular carcinoma, liver transplantation). 3 contact hours/year.

 

              Other clinical teaching: Internal medicine ward attending [internal medicine residents, 3rd year medical students] 4 weeks/year; hepatology clinic attending [GI fellows, residents] 3 half-days/week; liver transplant clinic [hepatology fellow] 2 half-days/week; hepatology consult rounds and didactic lectures [GI fellows, residents, 4th year medical studients] 7 days/month; endoscopy attending [GI fellows] 2 half-days/week.

 

              Guest lectures: Departments of Psychiatry, Dermatology, Pulmonary/Critical Care Medicine, Transplant Surgery, Department of Surgery, Anesthesiology.

             

              Teaching Awards:

                            VCU Outstanding Teacher Award, School of Medicine, for MII Clerkship, 2007.

 

 

SERVICE ACTIVITIES:

 

Clinical Service.

              Outpatient Activities

                            VCU Hepatology Private Practice

                            VCU Liver Transplant Clinic

                            VCU Endoscopy

                            VCU GI Fellows Clinic

                            VA Department of Corrections Hepatology Clinic

              Inpatient Activities

                            GI/Hepatology Medicine Wards (Digestive Health Service)

                            Hepatology Consult Service

                            Gastroenterology Consult Service (weekends)             

                            Endoscopy call rotation

 

Service to the Profession.

              Acute Liver Failure Study Group:

                            Executive Committee 2010-2013, 2016-present

                            STOP-ALF Steering Committee 2011-2016

                            Methacetin Breath Test Committee 2016-present

                            Rotational Thromboelastometry Committee (Chairman) 2016-                                                        present

                            Adjudication Committee 2016-present

                            ICU Management Protocol Subcommittee (Chairman) 2005-2007

                            Intracranial Pressure Monitoring Interest Group (Chairman) 2012.

                                          Ancillary Studies Committee (2001- 2006)

 

              Adult-to-adult Living Donor Liver Transplant (A2ALL) Consortium:

                            Publications Committee, 2005-2007 and 2013-2015.

                            Ancillary Studies Committee, 2013-2015.

                            HCV Subcommittee (Chairman), 2009-2015.             

 

              Practice Guidelines Committee, American Association for the Study of Liver               Diseases, 2013-2015

 

              Abstract Review Committee, Chairman; “Complications of Liver               Transplantation.” American Transplant Congress, 2013.

 

              Liver-Joint Societies Working Group for OPTN Living Donor Liver Policy               Development, 2012-13.

 

              UNOS/OPTN Medical Evaluation Subcommittee for Living Liver Donors,               2012-2014.

 

              UNOS Living Donor Committee (2010-2012, 2014-2015).

 

              Data Safety Monitoring Board, Ammonul in Hepatic Encephalopathy,               (2008-2009).

 

              American Association for the Study of Liver Diseases Abstract Selection               Committee, acute liver failure. Session moderator, annual meeting (2006-)

             

                            American Transplant Congress abstract selection (2006-2015). Session               moderator, annual meeting (2006-2014)

 

                            UNOS Living Donor Committee, Best Practices Subcommittee (2005-2006)             

                           

              UNOS Ad Hoc Living Donor Committee (2002-2006)             

 

              UNOS Living Donor Committee, Quality-of-Life Subcommittee (2002-                            2006).

 

                            American Association for the Study of Liver Diseases Education Committee               (1997-8).

 

              American Association for the Study of Liver Diseases Abstract Selection               Committee, categories in bile acid and cholesterol metabolism,               lipoproteins,               biotransformation, and metabolic/genetic liver diseases               (1997-9).

 

Service to the School of Medicine.

             

              Samira Shojaee, M.D. Promotion Committee (Division of Pulmonary and                                           Critical Care, VCU Department of Internal Medicine), 2018

              VCU Director of Transplant Administration Search Committee, 2018

              Jasmohan Bajaj, M.D. Tenure Committee (VCU Department of Internal                                           Medicine), 2018

              VCU Division of Transplant Surgery, Chief of Liver Transplantation Search                                           Committee, 2014

              VCU Division of Transplant Surgery Chairman Search Committee, 2013-14

              Diane M. Biskobing, M.D. Promotion Committee (Division of                                                                       Endocrinology), 2013

              JinXing Yu, M.D. Promotion Committee (Department of Radiology), 2012

              VCU Department of Neuropathology Internal Review Committee, 2007                             VCU Division of Gastroenterology Fellowship Director, 2006-2008

              VCU Graduate Medical Education Committee, 2006-2008

              MCV-VCU Library Committee, 1996-9

 

Service to the Department.

              VCU Division of Gastroenterology, Hepatology Faculty Search Committee,                                           2012-present

              VCU GI Fellow Clinical Competency Commmittee, 2003-present

              VCU Division of Hematology/Oncology Chair Search Committee 1998

              VCU/VAMC Liver Transplant Committee, 1997-present

VCU Department of Internal Medicine Council for Research 1998-9             

 

 

PUBLICATIONS

 

Papers in Peer-Reviewed Journals.

 

1. Hylemon, P.B., Gurley, E.C., Stravitz, R.T., Litz, J.S., Pandak, W.M., Chiang, J.Y.L., and Vlahcevic, Z.R: Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J Biol Chem. 267: 16866-16871, 1992.

 

2. Stravitz, R.T., Hylemon, P.B., Heuman, D.M., Hagey, L.R., Schteingart, C.D., Ton-Nu, H-T, Hofmann, A.F., and Vlahcevic, Z.R.: Transcriptional regulation of cholesterol 7α-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J Biol Chem. 268: 13987-13993, 1993.

 

3. Stravitz, R.T., Vlahcevic, Z.R., Pandak, W.M., Stolz, A., and Hylemon, P.B.: Regulation of rat hepatic 3α-hydroxysteroid dehydrogenase in vivo and in primary cultures of rat hepatocytes. J Lipid Res. 35: 239-247, 1994.

 

4. Stravitz, R.T., Vlahcevic, Z.R., Gurley, E.C., and Hylemon, P.B.: Repression of cholesterol 7α-hydroxylase transcription by bile acids in cultured rat hepatocytes is mediated through protein kinase C. J Lipid Res., 36: 1359-1369, 1995.

 

5. Stravitz, R.T., Vlahcevic, Z.R., Russell, T.R., and Hylemon, P.B.: Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes. J Steroid Biochem Mol Biol., 57: 337-347, 1996.

 

6. Pandak, W.M., Stravitz, R.T., Lucas, V., Heuman, D.M., and Chiang, J.Y.L.: Hep G2 cells: a model for studies on regulation of human cholesterol 7α-hydroxylase at the molecular level. Am J Physiol. 270: G401-G410, 1996.

 

7. Vlahcevic, Z.R., Jairath, S.K., Heuman, D.M., Stravitz, R.T., Hylemon, P.B., Avadhani, N.G., and Pandak, W.M.: Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids. Am J Physiol. 270: G646-G652, 1996.

 

8. Stravitz, R.T., Rao, Y., Vlahcevic, Z.R., Gurley, E.C., and Hylemon, P.B.: Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am J Physiol. 271: G293-G303, 1996.

 

9. Stravitz, R.T., Sanyal, A.S., Pandak, W.M., Vlahcevic, Z.R., Beets, J.W. and Dawson, P.A. Induction of apical sodium-dependent bile acid transporter mRNA, protein, and activity in rat ileum by intestinal cholic acid. Gastroenterology. 113: 1599-1608, 1997.