OMB No. 0925-0001 and 0925-0002 (Rev. 10/2021 Approved Through 01/31/2026)

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FIVE PAGES.

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

A. Personal Statement

As a dedicated researcher in the field of sickle cell disease (SCD), my work is driven by a passion to alleviate the burdens faced by individuals living with this condition. My research endeavors have focused on understanding the multifaceted aspects of SCD, ranging from its economic implications to exploring innovative interventions to improve patient outcomes.

The study conducted by Holdford et al. (2021) shed light on the significant indirect economic burden imposed by SCD, highlighting the pressing need for interventions that not only address clinical manifestations but also mitigate the socioeconomic challenges faced by patients and their families.

Building upon this foundation, our randomized controlled trial, led by Smith et al. (2022), demonstrated the efficacy of community health workers in improving hematologic variables and hydroxyurea adherence among individuals with SCD. This pioneering intervention offers a promising approach to enhancing patient care and treatment adherence, ultimately contributing to better health outcomes.

Furthermore, our investigation into the association between cerebral hemodynamics, anemia, and processing speed in adults with SCD, as outlined in Sop et al. (2023), provides valuable insights into the neurological manifestations of the disease. By elucidating the underlying mechanisms contributing to cognitive impairment in SCD, we aim to inform the development of targeted interventions to mitigate these effects and improve cognitive function in affected individuals.

In addition, our efforts to leverage technology for improving medication adherence in SCD, as evidenced by the development and validation of a mobile application, as described in Sop et al. (2022), underscore our commitment to harnessing innovative solutions to address the complex challenges faced by patients in managing their condition.

As I continue my journey in SCD research, I am driven by a steadfast commitment to advancing knowledge, improving patient care, and ultimately, making a meaningful difference in the lives of individuals affected by this debilitating disease.

1.      Sop D, Steinberg JL, Jordan J, Crouch T, Zhang Y, Smith W. Association of Cerebral Hemodynamics and Anemia on Processing Speed in Adults with Sickle Cell Disease. Journal of Neurology and Experimental Neural Science. 2023 July 24; 5(1). Available from: https://www.gavinpublishers.com/assets/articles_pdf/Association-of-Cerebral-Hemodynamics-and-Anemia-on-Processing-Speed-in-Adults-with-Sickle-Cell-Disease.pdf DOI: 10.29011/2577-1442.100050

2.      Sop D, Crouch T, Zhang Y, Lipato T, Wilson J, Smith W. Feasibility and Quality Validation of a Mobile Application for Enhancing Adherence to Opioids in Sickle Cell Disease. Healthcare. 2022 August 10; 10(8):1506-. Available from: https://www.mdpi.com/2227-9032/10/8/1506 DOI: 10.3390/healthcare10081506

3.      Smith WR, McClish DK, Lottenberg R, Sisler IY, Sop D, Johnson S, Villella A, Liles D, Yang E, Chen I. A randomised controlled provider-blinded trial of community health workers in sickle cell anaemia: effects on haematologic variables and hydroxyurea adherence. Br J Haematol. 2022 Jan;196(1):193-203. PubMed PMID: 34786695.

4.      Holdford D, Vendetti N, Sop DM, Johnson S, Smith WR. Indirect Economic Burden of Sickle Cell Disease. Value Health. 2021 Aug;24(8):1095-1101. PubMed PMID: 34372974.

B. Positions, Scientific Appointments and Honors

Positions and Scientific Appointments

Honors

C. Contribution to Science

a.                              Sop D, Steinberg JL, Jordan J, Crouch T, Zhang Y, Smith W. Association of Cerebral Hemodynamics and Anemia on Processing Speed in Adults with Sickle Cell Disease. Journal of Neurology and Experimental Neural Science. 2023 July 24; 5(1). Available from: https://www.gavinpublishers.com/assets/articles_pdf/Association-of-Cerebral-Hemodynamics-and-Anemia-on-Processing-Speed-in-Adults-with-Sickle-Cell-Disease.pdf DOI: 10.29011/2577-1442.100050

b.                              Sop D, Crouch T, Zhang Y, Lipato T, Wilson J, Smith W. Feasibility and Quality Validation of a Mobile Application for Enhancing Adherence to Opioids in Sickle Cell Disease. Healthcare. 2022 August 10; 10(8):1506-. Available from: https://www.mdpi.com/2227-9032/10/8/1506 DOI: 10.3390/healthcare10081506

c.                              Smith WR, McClish DK, Lottenberg R, Sisler IY, Sop D, Johnson S, Villella A, Liles D, Yang E, Chen I. A randomised controlled provider-blinded trial of community health workers in sickle cell anaemia: effects on haematologic variables and hydroxyurea adherence. Br J Haematol. 2022 Jan;196(1):193-203. PubMed PMID: 34786695.

d.                              Holdford D, Vendetti N, Sop DM, Johnson S, Smith WR. Indirect Economic Burden of Sickle Cell Disease. Value Health. 2021 Aug;24(8):1095-1101. PubMed PMID: 34372974.

a.                              Sop D, Smith W, Alsalman A, Li Wong J, Fei D, McClish D, Rafiq A, Coyne P, Johnson S, Lipato T. Survey of Physician Perspective towards Management of Pain for Chronic Conditions in the Emergency Department. Modern Clinical Medicine Research. 2017 October 11; 1(3):-. Available from: http://www.isaacpub.org/images/PaperPDF/MCMR_100022_2017101110205823647.pdf DOI: 10.22606/mcmr.2017.13002

Complete List of Published Work in My Bibliography:
https://www.ncbi.nlm.nih.gov/myncbi/daniel.sop.1/bibliography/public/