Curious Clinicians - The Forgotten Factor (2026)

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ONLINEABIM MOC Part 2AMAMOCPodcastsCurious CliniciansFactor 12 Deficiency

Instructions

Thursday, January 15, 2026, 3:30 PM - Thursday, December 31, 2026, 11:59 PM

Why doesn’t factor 12 deficiency cause bleeding?

In July 1953, freight brakeman John Hageman’s doctors faced a scenario that might feel familiar to anyone who has ever done preoperative medicine consults. Hageman had planned to undergo a partial gastrectomy for peptic ulcer disease, but his preoperative tests showed a prolonged clotting time. In the 1950s, we knew about other diseases with prolonged clotting times; hemophilia in particular, which at the time referred to what we now know as hemophilia A (Factor 8 deficiency) and hemophilia B (then known as Christmas disease and now known as Factor 9 deficiency). But Oscar Ratnoff and Joan Colopy, two scientists who investigated the case further, found a few things that made it clear Hageman didn’t have either condition. So why did he have a prolonged clotting time without any bleeding symptoms?

1. Describe the pathophysiology of Factor 12 deficiency.
2. Explain why Factor 12 deficiency does not result in a bleeding tendency.
3. Describe how Factor 12 deficiency led to understanding of the modern coagulation cascade.

There is a $10.00 Credit Claim fee to obtain CE credit for this activity. This Credit Claim fee will help to cover the costs of operational services, electronic reporting (if applicable), and real time customer service support. 

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• In order to receive continuing education credit, learners must listen to the 30 minute podcast, pass the post-test (2 questions, 100% required score, unlimited attempts), and complete an evaluation form. 

 

The planning committee members report having no relevant financial relationships to disclose:

Hannah Abrams 
Tony Breu
Avi Cooper

In support of improving patient care, this activity has been planned and implemented by Curious Clinicians and VCU Health Continuing Education. VCU Health Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

 

VCU Health Continuing Education designates this enduring material activity for a maximum of 0.75 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

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Minimum and maximum numbers for attendance at this event have been established, and we reserve the right to substitute speakers/topics, adjust credit hours, or cancel if necessary.

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AMA PRA Category 1 Credits™ (0.75 hours), ABIM MOC Part 2 (0.75 hours), Non-Physician Attendance (0.75 hours)

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